Why Does NAD Burn When Injected? Causes and Comfort Tips

NAD injections can sometimes cause a brief burning, stinging or warm sensation at the injection site. The experience varies from person to person and may be influenced by the formulation, injection site, temperature, technique and individual sensitivity.

Mild, short-lived discomfort may occur with an injection. However, severe pain or symptoms such as increasing redness, swelling, drainage, fever, chills, shaking, vomiting, hives or difficulty breathing require prompt medical attention. Always contact your healthcare professional when a reaction is unexpected or concerning.

What Is NAD?

Nicotinamide adenine dinucleotide, commonly called NAD or NAD+, is a coenzyme naturally present in the body’s cells. It participates in cellular energy metabolism and other biological processes.

NAD products are offered through different routes, including injectable and intravenous preparations. Formulations and directions can vary. Research into the claimed wellness benefits and long-term safety of injectable NAD remains limited, so treatment decisions should be made with a qualified healthcare professional.

Why Does NAD Burn When Injected?

There is not one universal explanation. Several factors may contribute to the sensation:

•  The needle activates sensory nerves. Any needle puncture can trigger a quick pinch, sting or burning signal in the skin.

•  The formulation may irritate local tissue. Concentration, pH and inactive ingredients can affect how an injection feels. Never dilute, mix or change the product unless your healthcare professional or pharmacist specifically instructs you to do so.

•  Temperature may affect comfort. A solution’s temperature can influence the sensation for some people. Follow the product’s storage and handling directions exactly, and never heat an injectable product.

•  Technique can influence the experience. Injection angle, site selection and other technique factors may matter. Use only the method taught by your healthcare professional and supplied with your medication and injection device.

•  The site may already be sensitive. Avoid injecting into skin that is bruised, swollen, scarred, hard, red or irritated unless your healthcare professional directs otherwise. Follow the recommended site-rotation plan.

•  Anxiety can intensify discomfort. Tensing the body and anticipating pain may make the sensation feel stronger. Slow breathing and relaxing the surrounding muscles may help.

Is It Normal for an NAD Injection to Sting?

A mild and brief sting can occur with an injection, but persistent or severe burning should not simply be ignored. Stop and contact your healthcare professional if discomfort is intense, worsening or accompanied by other symptoms.

Seek medical guidance promptly for increasing redness or warmth, swelling, a persistent lump, drainage, fever, chills, shaking, vomiting, severe fatigue, hives, facial swelling or difficulty breathing. Call emergency services for symptoms of a serious allergic reaction or other medical emergency.

The U.S. Food and Drug Administration has reported adverse events following the use of NAD+ injectable drugs, including severe chills, shaking, vomiting and fatigue; some cases required medical treatment. FDA stated that these reactions were consistent with excessive endotoxin levels.

Special Considerations for Compounded NAD

Many injectable NAD products are compounded. Compounded drugs are not FDA-approved, which means FDA does not verify their safety, effectiveness or quality before marketing in the same way it does for approved drugs.

Ask your healthcare professional or pharmacist:

·   Which pharmacy prepared the product and whether it is appropriately licensed

·   How the product should be stored and handled

·   Whether there are any recalls or product-quality alerts

·   Whom to contact if the product looks unusual or you experience a reaction

Do not use a product with a damaged seal, an expired date or an unexpected change in color, clarity or appearance. Contact the dispensing pharmacy or your healthcare professional for instructions.

How to Make an NAD Injection More Comfortable

1. Choose a healthy injection site. Follow the site-selection and rotation instructions provided by your healthcare professional.

2. Follow storage directions. Use the product only as directed. Do not warm, cool, dilute or alter it on your own.

3. Relax and breathe slowly. Release tension in the surrounding muscles and use steady breathing before and during the injection.

4. Redirect your attention. Music, conversation, a video or another simple distraction may make the moment feel less stressful.

5. Use gentle vibration near the injection site. Digivibe provides a competing sensory signal near the injection area to help make the needle experience more comfortable.

Clinically Evaluated Injection Comfort

Digivibe has been clinically evaluated for reducing needle-related discomfort during abdominal injections, vaccinations and fingersticks. Gentle vibration near the injection site is designed to provide the nervous system with a competing sensory signal during the needle procedure. Individual results vary.

Learn how Digivibe works   |   View the clinical research

Should You Continue Using NAD if It Burns?

Do not change the dose, concentration, schedule or injection technique on your own. Tell the prescribing healthcare professional what you felt, how long it lasted and whether you noticed redness, swelling or other symptoms. Your provider can determine whether the product, technique or treatment plan should be reviewed.

Make Your Next Injection More Comfortable

Digivibe is a compact, drug-free vibration device designed for use near the injection site before and during a needle procedure. It can be used at home, while traveling or during a medical appointment, as directed.

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Medical Disclaimer

Digivibe is an FDA-registered Class I device. This article is for general informational purposes and does not provide medical advice or establish that NAD injections are safe, effective or appropriate for any individual. Always follow the instructions supplied with your medication and injection device, and consult a qualified healthcare professional regarding injectable NAD, injection technique and unexpected reactions. Individual Digivibe results may vary.